RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks

The RAG recombinase (RAG1/2) plays an essential role in adaptive immunity by mediating V(D)J recombination in developing lymphocytes. In contrast, aberrant RAG1/2 activity promotes lymphocyte malignancies by causing chromosomal translocations and DNA deletions at cancer genes. RAG1/2 can also induce...

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Detalles Bibliográficos
Publicado en:J Exp Med
Main Authors: Rommel, Philipp C., Oliveira, Thiago Y., Nussenzweig, Michel C., Robbiani, Davide F.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339680/
https://ncbi.nlm.nih.gov/pubmed/28179379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161638
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