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RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks
The RAG recombinase (RAG1/2) plays an essential role in adaptive immunity by mediating V(D)J recombination in developing lymphocytes. In contrast, aberrant RAG1/2 activity promotes lymphocyte malignancies by causing chromosomal translocations and DNA deletions at cancer genes. RAG1/2 can also induce...
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| Publicado no: | J Exp Med |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5339680/ https://ncbi.nlm.nih.gov/pubmed/28179379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161638 |
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