DYNC1H1 mutations associated with neurological diseases compromise processivity of dynein–dynactin–cargo adaptor complexes

Mutations in the human DYNC1H1 gene are associated with neurological diseases. DYNC1H1 encodes the heavy chain of cytoplasmic dynein-1, a 1.4-MDa motor complex that traffics organelles, vesicles, and macromolecules toward microtubule minus ends. The effects of the DYNC1H1 mutations on dynein motilit...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Hoang, Ha Thi, Schlager, Max A., Carter, Andrew P., Bullock, Simon L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338514/
https://ncbi.nlm.nih.gov/pubmed/28196890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620141114
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