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On and off controls within dynein–dynactin on native cargoes

The dynein–dynactin nanomachine transports cargoes along microtubules in cells. Why dynactin interacts separately with the dynein motor and also with microtubules is hotly debated. Here we disrupted these interactions in a targeted manner on phagosomes extracted from cells, followed by optical trapp...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Sanghavi, Paulomi, Kumar, Pankaj, Roy, Ankit, Madhusudhan, M. S., Mallik, Roop
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2021
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201952/
https://ncbi.nlm.nih.gov/pubmed/34074788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2103383118
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