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Cargo adaptors regulate stepping and force generation of mammalian dynein-dynactin
Cytoplasmic dynein is an ATP-driven motor that transports intracellular cargos along microtubules. Dynein adopts an inactive conformation when not attached to cargo, and motility is activated when dynein assembles with dynactin and a cargo adaptor. It remained unclear how active dynein-dynactin comp...
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| Publicado en: | Nat Chem Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6810841/ https://ncbi.nlm.nih.gov/pubmed/31501589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0352-0 |
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