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Cargo adaptors regulate stepping and force generation of mammalian dynein-dynactin

Cytoplasmic dynein is an ATP-driven motor that transports intracellular cargos along microtubules. Dynein adopts an inactive conformation when not attached to cargo, and motility is activated when dynein assembles with dynactin and a cargo adaptor. It remained unclear how active dynein-dynactin comp...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Elshenawy, Mohamed M., Canty, John T., Oster, Liya, Ferro, Luke S., Zhou, Zhou, Blanchard, Scott C., Yildiz, Ahmet
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6810841/
https://ncbi.nlm.nih.gov/pubmed/31501589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0352-0
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