Heterozygosity for TACI A144E causes haploinsufficiency and pneumococcal susceptibility in mice

BACKGROUND: The B cell receptor TACI is important for T-independent antibody responses. One in 200 blood donors are heterozygous for the TACI A181E mutation. OBJECTIVE: To investigate the impact on B cell function of TACI A181E heterozygosity in reportedly healthy subjects and of the corresponding T...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Jabara, Haifa H., Lee, John J., Janssen, Erin, Ullas, Sumana, Liadaki, Kyriaki, Garibyan, Lilit, Benson, Halli, Sannikova, Tatyana, Bram, Richard, Hammarstrom, Lennart, Cruz, Anthony C., Siegel, Richard, Manis, John, Malley, Richard, Geha, Raif S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5337448/
https://ncbi.nlm.nih.gov/pubmed/27609654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.07.028
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