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TRIF signaling is essential for TLR4-driven IgE class switching
The TLR4 ligand LPS causes mouse B cells to undergo IgE and IgG1 isotype switching in the presence of IL-4. TLR4 activates two signaling pathways mediated by the adaptor molecules MyD88 and TRAM, which recruits TRIF. Following stimulation with LPS+IL-4, Tram(−/−) and Trif(−/−) B cells completely fai...
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| Autores principales: | , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3952935/ https://ncbi.nlm.nih.gov/pubmed/24532577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300909 |
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