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TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40
The isotype switch defect in CD40(−/−) mice is corrected by wild-type (WT) CD40 transgene, but not by a mutant CD40 transgene that does not bind tumor necrosis factor receptor-associated factors (TRAF) 2 and 3. To define the individual roles of TRAF2 and TRAF3 in CD40 activation of B cells, we intro...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2721683/ https://ncbi.nlm.nih.gov/pubmed/19228877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxp013 |
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