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TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40

The isotype switch defect in CD40(−/−) mice is corrected by wild-type (WT) CD40 transgene, but not by a mutant CD40 transgene that does not bind tumor necrosis factor receptor-associated factors (TRAF) 2 and 3. To define the individual roles of TRAF2 and TRAF3 in CD40 activation of B cells, we intro...

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Detalhes bibliográficos
Main Authors: Jabara, Haifa H., Weng, Yu, Sannikova, Tatyana, Geha, Raif S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721683/
https://ncbi.nlm.nih.gov/pubmed/19228877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxp013
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