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A novel single‐cell method provides direct evidence of persistent DNA damage in senescent cells and aged mammalian tissues
The DNA damage response (DDR) arrests cell cycle progression until DNA lesions, like DNA double‐strand breaks (DSBs), are repaired. The presence of DSBs in cells is usually detected by indirect techniques that rely on the accumulation of proteins at DSBs, as part of the DDR. Such detection may be bi...
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| 出版年: | Aging Cell |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5334542/ https://ncbi.nlm.nih.gov/pubmed/28124509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12573 |
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