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A novel single‐cell method provides direct evidence of persistent DNA damage in senescent cells and aged mammalian tissues

The DNA damage response (DDR) arrests cell cycle progression until DNA lesions, like DNA double‐strand breaks (DSBs), are repaired. The presence of DSBs in cells is usually detected by indirect techniques that rely on the accumulation of proteins at DSBs, as part of the DDR. Such detection may be bi...

詳細記述

保存先:
書誌詳細
出版年:Aging Cell
主要な著者: Galbiati, Alessandro, Beauséjour, Christian, d'Adda di Fagagna, Fabrizio
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5334542/
https://ncbi.nlm.nih.gov/pubmed/28124509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12573
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