Telomeric DNA damage is irreparable and causes persistent DNA damage response activation

The DNA damage response (DDR) arrests cell-cycle progression until damage is removed. DNA damage-induced cellular senescence is associated with persistent DDR. The molecular bases that distinguish transient from persistent DDR are unknown. Here we show that a large fraction of exogenously-induced pe...

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Detalhes bibliográficos
Main Authors: Fumagalli, Marzia, Rossiello, Francesca, Clerici, Michela, Barozzi, Sara, Cittaro, Davide, Kaplunov, Jessica M., Bucci, Gabriele, Dobreva, Miryana, Matti, Valentina, Beausejour, Christian M., Herbig, Utz, Longhese, Maria Pia, di Fagagna, Fabrizio d’Adda
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717580/
https://ncbi.nlm.nih.gov/pubmed/22426077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2466
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