Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing

The DNA damage response (DDR) orchestrates DNA repair and halts cell cycle. If damage is not resolved, cells can enter into an irreversible state of proliferative arrest called cellular senescence. Organismal ageing in mammals is associated with accumulation of markers of cellular senescence and DDR...

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Main Authors: Rossiello, Francesca, Herbig, Utz, Longhese, Maria Pia, Fumagalli, Marzia, d’Adda di Fagagna, Fabrizio
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217147/
https://ncbi.nlm.nih.gov/pubmed/25104620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2014.06.009
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