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Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions
In normal human somatic cells, telomere dysfunction causes cellular senescence, a stable proliferative arrest with tumour suppressing properties. Whether telomere dysfunction-induced senescence (TDIS) suppresses cancer growth in humans, however, is unknown. Here, we demonstrate that multiple and dis...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Nature Publishing Group
2012
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3395091/ https://ncbi.nlm.nih.gov/pubmed/22569128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.132 |
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