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Stable Cellular Senescence Is Associated with Persistent DDR Activation
The DNA damage response (DDR) is activated upon DNA damage generation to promote DNA repair and inhibit cell cycle progression in the presence of a lesion. Cellular senescence is a permanent cell cycle arrest characterized by persistent DDR activation. However, some reports suggest that DDR activati...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4207795/ https://ncbi.nlm.nih.gov/pubmed/25340529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110969 |
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