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A novel single‐cell method provides direct evidence of persistent DNA damage in senescent cells and aged mammalian tissues
The DNA damage response (DDR) arrests cell cycle progression until DNA lesions, like DNA double‐strand breaks (DSBs), are repaired. The presence of DSBs in cells is usually detected by indirect techniques that rely on the accumulation of proteins at DSBs, as part of the DDR. Such detection may be bi...
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| Publicado no: | Aging Cell |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5334542/ https://ncbi.nlm.nih.gov/pubmed/28124509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12573 |
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