Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

In normal human somatic cells, telomere dysfunction causes cellular senescence, a stable proliferative arrest with tumour suppressing properties. Whether telomere dysfunction-induced senescence (TDIS) suppresses cancer growth in humans, however, is unknown. Here, we demonstrate that multiple and dis...

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Main Authors: Suram, Anitha, Kaplunov, Jessica, Patel, Priyanka L, Ruan, Haihe, Cerutti, Aurora, Boccardi, Virginia, Fumagalli, Marzia, Di Micco, Raffaella, Mirani, Neena, Gurung, Resham Lal, Hande, Manoor Prakash, d'Adda di Fagagna, Fabrizio, Herbig, Utz
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395091/
https://ncbi.nlm.nih.gov/pubmed/22569128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.132
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