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Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence
Oncogene-induced senescence (OIS) is a critical tumor-suppressing mechanism that restrains cancer progression at premalignant stages, in part by causing telomere dysfunction. Currently it is unknown whether this proliferative arrest presents a stable and therefore irreversible barrier to cancer prog...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5003242/ https://ncbi.nlm.nih.gov/pubmed/27503890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602379113 |
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