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Senescence is an Endogenous Trigger for microRNA-Directed Transcriptional Gene Silencing in Human Cells

Cellular senescence is a tumour suppressor mechanism that is triggered by cancer-initiating or promoting events in mammalian cells. The molecular underpinnings for this stable arrest involve transcriptional repression of proliferation-promoting genes regulated by the retinoblastoma (Rb)/E2F represso...

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Detalhes bibliográficos
Publicado no:Nat Cell Biol
Main Authors: Benhamed, Moussa, Herbig, Utz, Ye, Tao, Dejean, Anne, Bischof, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423543/
https://ncbi.nlm.nih.gov/pubmed/22366686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2443
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