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ddClone: joint statistical inference of clonal populations from single cell and bulk tumour sequencing data

Next-generation sequencing (NGS) of bulk tumour tissue can identify constituent cell populations in cancers and measure their abundance. This requires computational deconvolution of allelic counts from somatic mutations, which may be incapable of fully resolving the underlying population structure....

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Dades bibliogràfiques
Publicat a:Genome Biol
Autors principals: Salehi, Sohrab, Steif, Adi, Roth, Andrew, Aparicio, Samuel, Bouchard-Côté, Alexandre, Shah, Sohrab P.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333399/
https://ncbi.nlm.nih.gov/pubmed/28249593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1169-3
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