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ddClone: joint statistical inference of clonal populations from single cell and bulk tumour sequencing data

Next-generation sequencing (NGS) of bulk tumour tissue can identify constituent cell populations in cancers and measure their abundance. This requires computational deconvolution of allelic counts from somatic mutations, which may be incapable of fully resolving the underlying population structure....

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Библиографические подробности
Опубликовано в: :Genome Biol
Главные авторы: Salehi, Sohrab, Steif, Adi, Roth, Andrew, Aparicio, Samuel, Bouchard-Côté, Alexandre, Shah, Sohrab P.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333399/
https://ncbi.nlm.nih.gov/pubmed/28249593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1169-3
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