The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of HoxA7 and HoxA9

Acute myelogenous leukemia (AML) is a high-risk hematopoietic malignancy caused by a variety of mutations, including genes encoding the cohesin complex. Recent studies have demonstrated that reduction in cohesin complex levels leads to enhanced self-renewal in hematopoietic stem and progenitors (HSP...

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Détails bibliographiques
Publié dans:Leukemia
Auteurs principaux: Fisher, Joseph B., Peterson, Jonathan, Reimer, Michael, Stelloh, Cary, Pulakanti, Kirthi, Gerbec, Zachary J., Abel, Alex M., Strouse, Jennifer Miksanek, Strouse, Christopher, McNulty, Maureen, Malarkannan, Subramaniam, Crispino, John D., Milanovich, Samuel, Rao, Sridhar
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5332284/
https://ncbi.nlm.nih.gov/pubmed/27554164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.240
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