The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of HoxA7 and HoxA9

Acute myelogenous leukemia (AML) is a high-risk hematopoietic malignancy caused by a variety of mutations, including genes encoding the cohesin complex. Recent studies have demonstrated that reduction in cohesin complex levels leads to enhanced self-renewal in hematopoietic stem and progenitors (HSP...

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Publicado en:Leukemia
Main Authors: Fisher, Joseph B., Peterson, Jonathan, Reimer, Michael, Stelloh, Cary, Pulakanti, Kirthi, Gerbec, Zachary J., Abel, Alex M., Strouse, Jennifer Miksanek, Strouse, Christopher, McNulty, Maureen, Malarkannan, Subramaniam, Crispino, John D., Milanovich, Samuel, Rao, Sridhar
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5332284/
https://ncbi.nlm.nih.gov/pubmed/27554164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.240
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