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Genome editing demonstrates that the −5 kb Nanog enhancer regulates Nanog expression by modulating RNAPII initiation and/or recruitment

Transcriptional enhancers have been defined by their ability to operate independent of distance and orientation in plasmid-based reporter assays of gene expression. At present, histone marks are used to identify and define enhancers but do not consider the endogenous role of an enhancer in the conte...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Agrawal, Puja, Blinka, Steven, Pulakanti, Kirthi, Reimer, Michael H., Stelloh, Cary, Meyer, Alison E., Rao, Sridhar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948488/
https://ncbi.nlm.nih.gov/pubmed/33334884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015152
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