DOT1L inhibitors block abnormal self-renewal induced by cohesin loss

Acute myeloid leukemia (AML) is a high-risk malignancy characterized by a diverse spectrum of somatic genetic alterations. The mechanisms by which these mutations contribute to leukemia development and how this informs the use of targeted therapies is critical to improving outcomes for patients. Imp...

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Publicado no:Sci Rep
Main Authors: Heimbruch, Katelyn E., Fisher, Joseph B., Stelloh, Cary T., Phillips, Emily, Reimer, Michael H., Wargolet, Adam J., Meyer, Alison E., Pulakanti, Kirthi, Viny, Aaron D., Loppnow, Jessica J., Levine, Ross L., Pulikkan, John Anto, Zhu, Nan, Rao, Sridhar
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8012605/
https://ncbi.nlm.nih.gov/pubmed/33790356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86646-9
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