In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

Targeted genome editing via engineered nucleases is an exciting area of biomedical research and holds potential for clinical applications. Despite rapid advances in the field, in vivo targeted transgene integration is still infeasible because current tools are inefficient(1), especially for non-divi...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Suzuki, Keiichiro, Tsunekawa, Yuji, Hernandez-Benitez, Reyna, Wu, Jun, Zhu, Jie, Kim, Euiseok J., Hatanaka, Fumiyuki, Yamamoto, Mako, Araoka, Toshikazu, Li, Zhe, Kurita, Masakazu, Hishida, Tomoaki, Li, Mo, Aizawa, Emi, Guo, Shicheng, Chen, Song, Goebl, April, Soligalla, Rupa Devi, Qu, Jing, Jiang, Tingshuai, Fu, Xin, Jafari, Maryam, Esteban, Concepcion Rodriguez, Berggren, W. Travis, Lajara, Jeronimo, Nuñez-Delicado, Estrella, Guillen, Pedro, Campistol, Josep M., Matsuzaki, Fumio, Liu, Guang-Hui, Magistretti, Pierre, Zhang, Kun, Callaway, Edward M., Zhang, Kang, Belmonte, Juan Carlos Izpisua
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331785/
https://ncbi.nlm.nih.gov/pubmed/27851729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature20565
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