In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

Targeted genome editing via engineered nucleases is an exciting area of biomedical research and holds potential for clinical applications. Despite rapid advances in the field, in vivo targeted transgene integration is still infeasible because current tools are inefficient(1), especially for non-divi...

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Publicat a:Nature
Autors principals: Suzuki, Keiichiro, Tsunekawa, Yuji, Hernandez-Benitez, Reyna, Wu, Jun, Zhu, Jie, Kim, Euiseok J., Hatanaka, Fumiyuki, Yamamoto, Mako, Araoka, Toshikazu, Li, Zhe, Kurita, Masakazu, Hishida, Tomoaki, Li, Mo, Aizawa, Emi, Guo, Shicheng, Chen, Song, Goebl, April, Soligalla, Rupa Devi, Qu, Jing, Jiang, Tingshuai, Fu, Xin, Jafari, Maryam, Esteban, Concepcion Rodriguez, Berggren, W. Travis, Lajara, Jeronimo, Nuñez-Delicado, Estrella, Guillen, Pedro, Campistol, Josep M., Matsuzaki, Fumio, Liu, Guang-Hui, Magistretti, Pierre, Zhang, Kun, Callaway, Edward M., Zhang, Kang, Belmonte, Juan Carlos Izpisua
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331785/
https://ncbi.nlm.nih.gov/pubmed/27851729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature20565
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