In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-Epigenetic Modulation

Current genome-editing systems generally rely on the creation of DNA double-strand breaks (DSBs). This may limit their utility in clinical therapies, as unwanted mutations caused by DSBs can have deleterious effects. The CRISPR/Cas9 system has recently been repurposed to enable target gene activatio...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Liao, Hsin-Kai, Hatanaka, Fumiyuki, Araoka, Toshikazu, Reddy, Pradeep, Wu, Min-Zu, Sui, Yinghui, Yamauchi, Takayoshi, Sakurai, Masahiro, O'Keefe, David, Nuñez, Estrella, Guillen, Pedro, Campistol, Josep M., Wu, Cheng-Jang, Lu, Li-Fan, Esteban, Concepcion Rodriguez, Izpisua Belmonte, Juan Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732045/
https://ncbi.nlm.nih.gov/pubmed/29224783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.10.025
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