In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

Aging is the major risk factor for many human diseases. In vitro studies have demonstrated that cellular reprogramming to pluripotency reverses cellular age, but alteration of the aging process through reprogramming has not been directly demonstrated in vivo. Here, we report that partial reprogrammi...

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Published in:Cell
Main Authors: Ocampo, Alejandro, Reddy, Pradeep, Martinez-Redondo, Paloma, Platero-Luengo, Aida, Hatanaka, Fumiyuki, Hishida, Tomoaki, Li, Mo, Lam, David, Kurita, Masakazu, Beyret, Ergin, Araoka, Toshikazu, Vazquez-Ferrer, Eric, Donoso, David, Roman, Jose Luis, Xu, Jinna, Esteban, Concepcion Rodriguez, Nuñez, Gabriel, Delicado, Estrella Nuñez, Campistol, Josep M., Guillen, Isabel, Guillen, Pedro, Belmonte, Juan Carlos Izpisua
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679279/
https://ncbi.nlm.nih.gov/pubmed/27984723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.11.052
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