Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction

In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases. However, it remains a challenge to develop universal and efficient in vivo genome-editing tools for tissues that comprise diverse cell types in either a dividing or non-dividin...

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Publicado no:Cell Res
Main Authors: Suzuki, Keiichiro, Yamamoto, Mako, Hernandez-Benitez, Reyna, Li, Zhe, Wei, Christopher, Soligalla, Rupa Devi, Aizawa, Emi, Hatanaka, Fumiyuki, Kurita, Masakazu, Reddy, Pradeep, Ocampo, Alejandro, Hishida, Tomoaki, Sakurai, Masahiro, Nemeth, Amy N., Nuñez Delicado, Estrella, Campistol, Josep M., Magistretti, Pierre, Guillen, Pedro, Rodriguez Esteban, Concepcion, Gong, Jianhui, Yuan, Yilin, Gu, Ying, Liu, Guang-Hui, López-Otín, Carlos, Wu, Jun, Zhang, Kun, Izpisua Belmonte, Juan Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796851/
https://ncbi.nlm.nih.gov/pubmed/31444470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-019-0213-0
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