Synthesis and Biological Evaluation of Vitamin D3 Metabolite 20S,23S-Dihydroxyvitamin D3 and Its 23R Epimer

The vitamin D3 metabolite, 20S,23S-dihydroxyvitamin D3, was chemically synthesized for the first time and identified to be the same as the enzymatically produced metabolite. The C23 absolute configurations of both 20S,23S/R-dihydroxyvitamin D3 epimers were unambiguously assigned by NMR and Mosher es...

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Udgivet i:J Med Chem
Main Authors: Lin, Zongtao, Marepally, Srinivasa R., Ma, Dejian, Kim, Tae-Kang, Oak, Allen SW., Myers, Linda K., Tuckey, Robert C., Slominski, Andrzej T., Miller, Duane D., Li, Wei
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330258/
https://ncbi.nlm.nih.gov/pubmed/27070779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00182
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