Metabolism of 20-Hydroxyvitamin D3 and 20,23-Dihydroxyvitamin D3 by Rat and Human CYP24A1

CYP11A1 hydroxylates vitamin D3 producing 20S-hydroxyvitamin D3 [20(OH)D3] and 20S,23-dihydroxyvitamin D3 [20,23(OH)(2)D3] as the major and most characterized metabolites. Both display immuno-regulatory and anti-cancer properties while being non-calcemic. A previous study indicated 20(OH)D3 can be m...

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Gepubliceerd in:J Steroid Biochem Mol Biol
Hoofdauteurs: Tieu, Elaine W., Li, Wei, Chen, Jianjun, Kim, Tae-Kang, Ma, Dejian, Slominski, Andrzej T., Tuckey, Robert C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380815/
https://ncbi.nlm.nih.gov/pubmed/25727742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2015.02.010
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