Purified Mouse CYP27B1 Can Hydroxylate 20,23-Dihydroxyvitamin D(3), Producing 1α,20,23-Trihydroxyvitamin D(3), Which Has Altered Biological Activity

20,23-Dihydroxyvitamin D(3) [20,23(OH)(2)D(3)] is a biologically active metabolite produced by the action of cytochrome P450scc (CYP11A1) on vitamin D(3). It inhibits keratinocyte proliferation, stimulates differentiation, and inhibits nuclear factor-κB activity, working as a vitamin D receptor agon...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Tang, Edith K. Y., Li, Wei, Janjetovic, Zorica, Nguyen, Minh N., Wang, Zhao, Slominski, Andrzej, Tuckey, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939470/
https://ncbi.nlm.nih.gov/pubmed/20554701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.034389
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares