Chemical Synthesis and Biological Activities of 20S,24S/R-Dihydroxyvitamin D3 Epimers and Their 1α-Hydroxyl Derivatives

[Image: see text] Bioactive vitamin D3 metabolites 20S,24S-dihydroxyvitamin D3 [20S,24S(OH)(2)D3] and 20S,24R-dihydroxyvitamin D3 [20S,24R(OH)(2)D3] were chemically synthesized and confirmed to be identical to their enzymatically generated counterparts. The absolute configurations at C24 and its inf...

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Pubblicato in:J Med Chem
Autori principali: Lin, Zongtao, Marepally, Srinivasa Reddy, Ma, Dejian, Myers, Linda K., Postlethwaite, Arnold E., Tuckey, Robert C., Cheng, Chloe Y. S., Kim, Tae-Kang, Yue, Junming, Slominski, Andrzej T., Miller, Duane D., Li, Wei
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613797/
https://ncbi.nlm.nih.gov/pubmed/26367019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00881
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