Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice

ATP-binding cassette transporter A1 (ABCA1) controls cholesterol and phospholipid efflux to lipid-poor apolipoprotein E (APOE) and is transcriptionally controlled by Liver X receptors (LXRs) and Retinoic X Receptors (RXRs). In APP transgenic mice, lack of Abca1 increased Aβ deposition and cognitive...

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Vydáno v:PLoS One
Hlavní autoři: Carter, Alexis Y., Letronne, Florent, Fitz, Nicholas F., Mounier, Anais, Wolfe, Cody M., Nam, Kyong Nyon, Reeves, Valerie L., Kamboh, Hafsa, Lefterov, Iliya, Koldamova, Radosveta
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328633/
https://ncbi.nlm.nih.gov/pubmed/28241068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172161
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