Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice

ATP-binding cassette transporter A1 (ABCA1) controls cholesterol and phospholipid efflux to lipid-poor apolipoprotein E (APOE) and is transcriptionally controlled by Liver X receptors (LXRs) and Retinoic X Receptors (RXRs). In APP transgenic mice, lack of Abca1 increased Aβ deposition and cognitive...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Carter, Alexis Y., Letronne, Florent, Fitz, Nicholas F., Mounier, Anais, Wolfe, Cody M., Nam, Kyong Nyon, Reeves, Valerie L., Kamboh, Hafsa, Lefterov, Iliya, Koldamova, Radosveta
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328633/
https://ncbi.nlm.nih.gov/pubmed/28241068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172161
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge