ABCA1 haplodeficiency affects the brain transcriptome following traumatic brain injury in mice expressing human APOE isoforms

Expression of human Apolipoprotein E (APOE) modulates the inflammatory response in an isoform specific manner, with APOE4 isoform eliciting a stronger pro-inflammatory response, suggesting a possible mechanism for worse outcome following traumatic brain injury (TBI). APOE lipidation and stability is...

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Dades bibliogràfiques
Publicat a:Acta Neuropathol Commun
Autors principals: Castranio, Emilie L., Wolfe, Cody M., Nam, Kyong Nyon, Letronne, Florent, Fitz, Nicholas F., Lefterov, Iliya, Koldamova, Radosveta
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6062955/
https://ncbi.nlm.nih.gov/pubmed/30049279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0569-2
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