Induction of alternative proinflammatory cytokines accounts for sustained psoriasiform skin inflammation in IL-17C+IL-6KO mice

IL-6 inhibition has been unsuccessful in treating psoriasis, despite high levels of tissue and serum IL-6 in patients. Additionally, de novo psoriasis onset has been reported following IL-6 blockade in rheumatoid arthritis patients. To explore mechanisms underlying these clinical observations, we ba...

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Vydáno v:J Invest Dermatol
Hlavní autoři: Fritz, Yi, Klenotic, Philip A., Swindell, William R., Yin, ZhiQiang, Groft, Sarah G., Zhang, Li, Baliwag, Jaymie, Camhi, Maya I., Diaconu, Doina, Young, Andrew B., Foster, Alexander M., Johnston, Andrew, Gudjonsson, Johann E., McCormick, Thomas S., Ward, Nicole L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5326585/
https://ncbi.nlm.nih.gov/pubmed/27984037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2016.10.021
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