KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease

Kallikrein-related peptidase 6 (KLK6) is a secreted serine protease hypothesized to promote inflammation via cleavage of protease-activated receptor 1 (PAR1) and PAR2. KLK6 levels are elevated in multiple inflammatory and autoimmune conditions, but no definitive role in pathogenesis has been establi...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Billi, Allison C., Ludwig, Jessica E., Fritz, Yi, Rozic, Richard, Swindell, William R., Tsoi, Lam C., Gruzska, Dennis, Abdollahi-Roodsaz, Shahla, Xing, Xianying, Diaconu, Doina, Uppala, Ranjitha, Camhi, Maya I., Klenotic, Philip A., Sarkar, Mrinal K., Husni, M. Elaine, Scher, Jose U., McDonald, Christine, Kahlenberg, J. Michelle, Midura, Ronald J., Gudjonsson, Johann E., Ward, Nicole L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2020
Teme:
Concise Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260032/
https://ncbi.nlm.nih.gov/pubmed/32155135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI133159
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki