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Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation
IL-17C is a functionally distinct member of the IL-17 family that binds IL-17RE/A to promote innate defense in epithelial cells and regulate Th17 cell differentiation. We demonstrate that IL-17C (not IL-17A) is the most abundant IL-17 isoform in lesional psoriasis skin (1058pg/ml vs. 8pg/ml; p<0....
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3577967/ https://ncbi.nlm.nih.gov/pubmed/23359500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201505 |
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