Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

IL-17C is a functionally distinct member of the IL-17 family that binds IL-17RE/A to promote innate defense in epithelial cells and regulate Th17 cell differentiation. We demonstrate that IL-17C (not IL-17A) is the most abundant IL-17 isoform in lesional psoriasis skin (1058pg/ml vs. 8pg/ml; p<0....

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Main Authors: Johnston, Andrew, Fritz, Yi, Dawes, Sean M., Diaconu, Doina, Al-Attar, Paul M., Guzman, Andrew M., Chen, Cynthia S., Fu, Wen, Gudjonsson, Johann E., McCormick, Thomas S., Ward, Nicole L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577967/
https://ncbi.nlm.nih.gov/pubmed/23359500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201505
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