Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis

BACKGROUND: Imiquimod (IMQ) produces a cutaneous phenotype in mice frequently studied as an acute model of human psoriasis. Whether this phenotype depends on strain or sex has never been systematically investigated on a large scale. Such effects, however, could lead to conflicts among studies, while...

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Dettagli Bibliografici
Pubblicato in:Genome Med
Autori principali: Swindell, William R., Michaels, Kellie A., Sutter, Andrew J., Diaconu, Doina, Fritz, Yi, Xing, Xianying, Sarkar, Mrinal K., Liang, Yun, Tsoi, Alex, Gudjonsson, Johann E., Ward, Nicole L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345243/
https://ncbi.nlm.nih.gov/pubmed/28279190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-017-0415-3
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