RNA-seq identifies a diminished differentiation gene signature in primary monolayer keratinocytes grown from lesional and uninvolved psoriatic skin

Keratinocyte (KC) hyper-proliferation and epidermal thickening are characteristic features of psoriasis lesions, but the specific contributions of KCs to plaque formation are not fully understood. This study used RNA-seq to investigate the transcriptome of primary monolayer KC cultures grown from le...

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Publicado en:Sci Rep
Autores principales: Swindell, William R., Sarkar, Mrinal K., Liang, Yun, Xing, Xianying, Baliwag, Jaymie, Elder, James T., Johnston, Andrew, Ward, Nicole L., Gudjonsson, Johann E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741737/
https://ncbi.nlm.nih.gov/pubmed/29273799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18404-9
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