RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature

IL-36 cytokines have recently emerged as mediators of inflammation in autoimmune conditions including psoriasis vulgaris (PsV) and generalized pustular psoriasis (GPP). This study used RNA-seq to profile the transcriptome of primary epidermal keratinocytes (KCs) treated with IL-1B, IL-36A, IL-36B, o...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Swindell, William R., Beamer, Maria A., Sarkar, Mrinal K., Loftus, Shannon, Fullmer, Joseph, Xing, Xianying, Ward, Nicole L., Tsoi, Lam C., Kahlenberg, Michelle J., Liang, Yun, Gudjonsson, Johann E.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796909/
https://ncbi.nlm.nih.gov/pubmed/29434599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00080
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