Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter

Morphine shows large interindividual variability in its pharmacokinetics; however, the cause of this has not been fully addressed. The variability in morphine disposition is considered to be due to a combination of pharmacogenetic and physiological determinants related to morphine disposition. We pr...

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Pubblicato in:CPT Pharmacometrics Syst Pharmacol
Autori principali: Emoto, C, Fukuda, T, Johnson, TN, Neuhoff, S, Sadhasivam, S, Vinks, AA
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321811/
https://ncbi.nlm.nih.gov/pubmed/27935268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12144
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