Next challenge from the variance in individual PBPK model-predicted to observed morphine concentration in critically ill neonates

Ítems similars

• PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants
  per: Emoto, Chie, et al.
  Publicat: (2018)
• Model-informed Bayesian Estimation Improves the Prediction of Morphine Exposure in Neonates and Infants
  per: Euteneuer, Joshua C., et al.
  Publicat: (2020)
• Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children
  per: Hahn, David, et al.
  Publicat: (2017)
• Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter
  per: Emoto, C, et al.
  Publicat: (2016)
• Utilizing pediatric PBPK models to examine factors which contribute to methadone pharmacokinetic variability in neonatal abstinence syndrome patients
  per: McPhail, Brooks T., et al.
  Publicat: (2019)