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Utilizing pediatric PBPK models to examine factors which contribute to methadone pharmacokinetic variability in neonatal abstinence syndrome patients
Chronic intrauterine exposure to psychoactive drugs often results in neonatal abstinence syndrome (NAS). NAS is the symptomatic drug-withdrawal in newborns that generally occurs after in utero chronic opioid exposure. Methadone is a narcotic analgesic commonly prescribed for pharmacologic management...
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| Udgivet i: | J Clin Pharmacol |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7336467/ https://ncbi.nlm.nih.gov/pubmed/31820437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1538 |
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