PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants

Morphine has large pharmacokinetic variability, which is further complicated by developmental changes in neonates and small infants. The impacts of organic cation transporter 1 (OCT1) genotype and changes in blood‐flow on morphine clearance (CL) were previously demonstrated in children, whereas chan...

Szczegółowa specyfikacja

Zapisane w:
Opis bibliograficzny
Wydane w:CPT Pharmacometrics Syst Pharmacol
Główni autorzy: Emoto, Chie, Johnson, Trevor N., Neuhoff, Sibylle, Hahn, David, Vinks, Alexander A., Fukuda, Tsuyoshi
Format: Artigo
Język:Inglês
Wydane: John Wiley and Sons Inc. 2018
Hasła przedmiotowe:
Research
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063742/
https://ncbi.nlm.nih.gov/pubmed/29920988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12306
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