Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma

Efforts to identify and target glioblastoma (GBM) drivers have primarily focused on receptor tyrosine kinases (RTKs). Clinical benefits, however, have been elusive. Here, we identify a SRY-related box 2 (SOX2) transcriptional regulatory network that is independent of upstream RTKs and is capable of...

詳細記述

保存先:
書誌詳細
出版年:Cell Rep
主要な著者: Singh, Dinesh K., Kollipara, Rahul K., Vemireddy, Vamsidara, Yang, Xiao-Li, Sun, Yuxiao, Regmi, Nanda, Klingler, Stefan, Hatanpaa, Kimmo J., Raisanen, Jack, Cho, Steve K., Sirasanagandla, Shyam, Nannepaga, Suraj, Piccirillo, Sara, Mashimo, Tomoyuki, Wang, Shan, Humphries, Caroline G., Mickey, Bruce, Maher, Elizabeth, Zheng, Hongwu, Kim, Ryung S., Kittler, Ralf, Bachoo, Robert
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321610/
https://ncbi.nlm.nih.gov/pubmed/28122245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.12.064
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