Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma

Efforts to identify and target glioblastoma (GBM) drivers have primarily focused on receptor tyrosine kinases (RTKs). Clinical benefits, however, have been elusive. Here, we identify a SRY-related box 2 (SOX2) transcriptional regulatory network that is independent of upstream RTKs and is capable of...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Singh, Dinesh K., Kollipara, Rahul K., Vemireddy, Vamsidara, Yang, Xiao-Li, Sun, Yuxiao, Regmi, Nanda, Klingler, Stefan, Hatanpaa, Kimmo J., Raisanen, Jack, Cho, Steve K., Sirasanagandla, Shyam, Nannepaga, Suraj, Piccirillo, Sara, Mashimo, Tomoyuki, Wang, Shan, Humphries, Caroline G., Mickey, Bruce, Maher, Elizabeth, Zheng, Hongwu, Kim, Ryung S., Kittler, Ralf, Bachoo, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321610/
https://ncbi.nlm.nih.gov/pubmed/28122245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.12.064
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