Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors

Tumor-associated macrophages (TAM) and myofibroblasts are key drivers in cancer that are associated with drug resistance in many cancers, including pancreatic ductal adenocarcinoma (PDAC). However, our understanding of the molecular mechanisms by which TAM and fibroblasts contribute to chemoresistan...

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Pubblicato in:Cancer Res
Autori principali: Ireland, Lucy, Santos, Almudena, Ahmed, Muhammad S., Rainer, Carolyn, Nielsen, Sebastian R., Quaranta, Valeria, Weyer-Czernilofsky, Ulrike, Engle, Danielle D., Perez-Mancera, Pedro A., Coupland, Sarah E., Taktak, Azzam, Bogenrieder, Thomas, Tuveson, David A., Campbell, Fiona, Schmid, Michael C., Mielgo, Ainhoa
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321488/
https://ncbi.nlm.nih.gov/pubmed/27742686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1201
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