Macrophage-derived granulin drives resistance to immune checkpoint inhibition in metastatic pancreatic cancer

The ability of disseminated cancer cells to evade the immune response is a critical step for efficient metastatic progression. Protection against an immune attack is often provided by the tumor microenvironment that suppresses and excludes cytotoxic CD8(+) T cells. Pancreatic ductal adenocarcinoma (...

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Udgivet i:Cancer Res
Main Authors: Quaranta, Valeria, Rainer, Carolyn, Nielsen, Sebastian R., Raymant, Meirion L., Ahmed, Muhammad S., Engle, Dannielle D., Taylor, Arthur, Murray, Trish, Campbell, Fiona, Palmer, Daniel H., Tuveson, David A., Mielgo, Ainhoa, Schmid, Michael C.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6076440/
https://ncbi.nlm.nih.gov/pubmed/29789416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-3876
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