Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis

Pancreatic ductal adenocarcinoma (PDAC) is a devastating metastatic disease for which better therapies are urgently needed. Macrophages enhance metastasis in many cancer types, however, the role of macrophages in PDAC liver metastasis remains poorly understood. Here we found that PDAC liver metastas...

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Опубликовано в: :Nat Cell Biol
Главные авторы: Nielsen, Sebastian R, Quaranta, Valeria, Linford, Andrea, Emeagi, Perpetua, Rainer, Carolyn, Santos, Almudena, Ireland, Lucy, Sakai, Takao, Sakai, Keiko, Kim, Yong-Sam, Engle, Dannielle, Campbell, Fiona, Palmer, Daniel, Ko, Jeong Heon, Tuveson, David A., Hirsch, Emilio, Mielgo, Ainhoa, Schmid, Michael C
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894551/
https://ncbi.nlm.nih.gov/pubmed/27088855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3340
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